DWScript Just-In-Time compiler
For a couple months now, a JIT compiler has been available in the DWScript SVN for 32bits code. The JIT is meant to be transparent, that is, execution, debugging facilities and memory layouts are similar under JIT and interpretation, the only difference is the performance.
The JIT also uses a hybrid architecture, which was designed to allow developing the JIT incrementally, which directly derives from my only working on it a few hours at a time, every once in a while.
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Worst thing in popularity is not being considered, or found.